Karandeniya Central College is a high school situated in Galle District of Southern Province of Sri Lanka.
The main building was declared open in 1953 by the Minister of Education M. D. Banda. The College is one of the early schools that offered science education in Sinhalese in Sri Lanka. Two students qualified to enter the University of Ceylon in science in the Sinhalese language from the first batch of graduates in 1961. They are now university professors. The next batch produced one civil engineer who studied at Moscow University. The third batch produced one engineer who studied at the University of Sri Lanka and one doctor who studied in East Germany. Thereafter hundreds of students got admission to various universities in Sri Lanka and abroad from the Sinhalese programme. At present it could become one of the best colleges in southern province. Generally it is providing more than 50 student for Sri Lanka Universies per year.